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He, Chuan
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overview Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.
One or more keywords matched the following items that are connected to He, Chuan
Item TypeName
Concept Catalysis
Concept Enzyme Inhibitors
Concept Click Chemistry
Concept DNA Repair Enzymes
Concept Gene Expression Regulation, Enzymologic
Concept Enzyme Stability
Academic Article The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.
Academic Article Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Academic Article A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Academic Article Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA.
Academic Article Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Academic Article Silver-catalyzed intermolecular amination of C--H groups.
Academic Article Chemical methods to study protein-nucleic acid interactions.
Academic Article Platinum(II)-catalyzed intramolecular cyclization of o-substituted aryl alkynes through sp3 C-H activation.
Academic Article How do DNA repair proteins locate potential base lesions? a chemical crosslinking method to investigate O6-alkylguanine-DNA alkyltransferases.
Academic Article Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.
Academic Article A non-heme iron-mediated chemical demethylation in DNA and RNA.
Academic Article Cancer: Damage prevention targeted.
Academic Article Bioorthogonal labeling of 5-hydroxymethylcytosine in genomic DNA and diazirine-based DNA photo-cross-linking probes.
Academic Article An Au-catalyzed cyclialkylation of electron-rich arenes with epoxides to prepare 3-chromanols.
Academic Article Steady-state hydrogen peroxide induces glycolysis in Staphylococcus aureus and Pseudomonas aeruginosa.
Academic Article Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.
Academic Article Gold-catalyzed organic transformations.
Academic Article Modeling non-heme iron proteins.
Academic Article Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.
Academic Article Gold(I)-catalyzed formation of 3-pyrazolines through cycloaddition of diaziridine to alkynes.
Academic Article Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(a)I.
Academic Article High-Resolution Mapping of N6-Methyladenosine in Transcriptome and Genome Using a Photo-Crosslinking-Assisted Strategy.
Academic Article Preparation of Human Nuclear RNA m6A Methyltransferases and Demethylases and Biochemical Characterization of Their Catalytic Activity.
Academic Article Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article Characterization of eukaryotic DNA N(6)-methyladenine by a highly sensitive restriction enzyme-assisted sequencing.
Academic Article Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution.
Academic Article ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
Academic Article Development of Mild Chemical Catalysis Conditions for m1A-to-m6A Rearrangement on RNA.
Academic Article Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination.
Concept AlkB Enzymes
Grant Discovering the epigenetics of RNA modifications
Grant RNA methylation and regulatory T cells
Grant Predoctoral Training Program in Chemistry and Biology - Renewal 01
Academic Article Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA.
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  • chemistry
  • enzyme
  • catalysis